Controlling instabilities in manipulation requires specific cortical-striatal-cerebellar networks.

Neurophysiol Francisco J . Valero - Cuevas Kristine Mosier , Chad Lau , Yang Wang , Madhusudhan Venkadesan and specific cortical - striatal - cerebellar networks Controlling instabilities in manipulation requires

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44 Dexterous manipulation requires both “strength”, the ability to produce fingertip 45 forces of a specific magnitude; and “dexterity”, the ability to dynamically regulate the 46 magnitude and direction of fingertip force vectors and finger motions. While cortical 47 activity in fronto-parietal networks has been established for stable grip and pinch forces, 48 the cortical regulation in the de...

Cerebellar Influence on Motor Cortex Plasticity: Behavioral Implications for Parkinson’s Disease

Normal motor behavior involves the creation of appropriate activity patterns across motor networks, enabling firing synchrony, synaptic integration, and normal functioning of these networks. Strong topography-specific connections among the basal ganglia, cerebellum, and their projections to overlapping areas in the motor cortices suggest that these networks could influence each other's plastic ...

Disrupted cortico-cerebellar connectivity in older adults

Healthy aging is marked by declines in a variety of cognitive and motor abilities. A better understanding of the aging brain may aid in elucidating the neural substrates of these behavioral effects. Investigations of resting state functional brain connectivity have provided insights into pathology, and to some degree, healthy aging. Given the role of the cerebellum in both motor and cognitive b...

L-NAME and 7-Nitroindazole Reduces Brain Injuries in Transient Focal Cerebral Ischemia in Rat

Background: The role of nitric oxide (NO) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all.  Objective: To investigate the role of NO of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, L-NAME, a non selective NO synthase inhibitor...